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Current Studies
Epistry
Hypertonic Saline
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Current Studies
The primary goal of the Epistry Database working group is to develop the rationale and methods for a standard reliable and valid Epidemiologic databank of out of hospital cardiac arrest and life threatening trauma cases with in-hospital outcomes after 5 years enabling the identification of best practices via observational study and mega trials with the ultimate goal of improving resuscitation success defined as survival to hospital discharge rates across ROC centers.
This is a proposal for two multicenter trials of hypertonic resuscitation in two populations of trauma patients to be conducted simultaneously using the same intervention and infrastructure. Study 1 seeks to determine the impact of hypertonic resuscitation on survival for blunt or penetrating trauma patients in hypovolemic shock. Study 2 seeks to determine the impact of hypertonic resuscitation on long term (6 month) neurologic outcome for blunt trauma patients with severe traumatic brain injury. Both studies will be three arm, randomized, blinded intervention trials comparing hypertonic saline/ dextran (7.5% saline/6% dextran 70, HSD), hypertonic saline alone (7.5% saline, HS), and normal saline (NS) as the initial resuscitation fluid administered to these patients in the prehospital setting.